Rekombinanter TFEB Antikörper (AA 426-476)

Produktnummer ABIN7453326

Dieses Anti-TFEB-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von TFEB in WB und IP. Geeignet für Human und Maus.

Kurzübersicht für Rekombinanter TFEB Antikörper (AA 426-476) (ABIN7453326)

Target: TFEB (Transcription Factor EB (TFEB))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TFEB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Klon: BLR070G

Produktdetails anti-TFEB Antikörper

Bindungsspezifität: AA 426-476

Verwendungszweck: Rabbit anti-TFEB Recombinant Monoclonal Antibody [BLR070G]

Immunogen: between AA 426 and 476 (C-term)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20 μL/1 mg lysate

WB: 17:40:00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TFEB

Target: TFEB (Transcription Factor EB (TFEB))

Andere Bezeichnung: TFEB

Hintergrund: Background: Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) P19484].

Gen-ID: 7942

NCBI Accession: NP_009093

UniProt: P19484