Rekombinanter PD-L1 Antikörper (AA 19-238)

Produktnummer ABIN7453318

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch PD-L1 in WB und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter PD-L1 Antikörper (AA 19-238) (ABIN7453318)

Target: PD-L1 (CD274 (PD-L1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PD-L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Klon: BLR227K

Produktdetails anti-PD-L1 Antikörper

Bindungsspezifität: AA 19-238

Verwendungszweck: Rabbit anti-PD-L1 Recombinant Monoclonal Antibody [BLR227K]

Immunogen: residues 19-238 (ECD)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20 μL/1 mg lysate

WB: 01:01,00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PD-L1

Target: PD-L1 (CD274 (PD-L1))

Andere Bezeichnung: PD-L1

Hintergrund: Background: PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].

Gen-ID: 29126

NCBI Accession: NP_054862

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints