Transferrin Receptor Antikörper (AA 125-175)

Produktnummer ABIN7453217

Der Kaninchen Polyklonal Anti-Transferrin Receptor-Antikörper wurde für WB validiert. Er ist geeignet, Transferrin Receptor in Proben von Human zu detektieren.

Kurzübersicht für Transferrin Receptor Antikörper (AA 125-175) (ABIN7453217)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Transferrin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Transferrin Receptor Antikörper

Bindungsspezifität: AA 125-175

Verwendungszweck: Rabbit anti-TfR Antibody, Affinity Purified

Homologie: Dog,Horse,Orangutan

Aufreinigung: Affinity Purified

Immunogen: Between AA 125 and 175

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: Not recommended

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung: TfR

Hintergrund: Background: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor (TR) into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site [taken from the Universal Protein Resource (UniProt) P02786].

Gen-ID: 7037

NCBI Accession: NP_003225

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis