Rekombinanter TIM3 Antikörper (AA 231-281)

Produktnummer ABIN7452586

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch TIM3 in WB und IP. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für Rekombinanter TIM3 Antikörper (AA 231-281) (ABIN7452586)

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TIM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Klon: BLR207K

Produktdetails anti-TIM3 Antikörper

Bindungsspezifität: AA 231-281

Verwendungszweck: Rabbit anti-TIM3 Recombinant Monoclonal Antibody [BLR207K]

Immunogen: between AA 231 and 281 (C-term)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20 μL/1 mg lysate

WB: 01:01,00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TIM3

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Andere Bezeichnung: TIM3

Substanzklasse: Virus

Hintergrund: Background: TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.  [taken from the Universal Protein Resource (UniProt) Q8TDQ0].

Gen-ID: 171285

NCBI Accession: NP_599011

UniProt: Q8VIM0

Pathways: Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints