Rekombinanter EPH Receptor A2 Antikörper (AA 25-534)

Produktnummer ABIN7452579

Dieses Anti-EPH Receptor A2-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von EPH Receptor A2 in WB und IP. Geeignet für Human.

Kurzübersicht für Rekombinanter EPH Receptor A2 Antikörper (AA 25-534) (ABIN7452579)

Target: EPH Receptor A2 (EPHA2)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser EPH Receptor A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Klon: BLR136H

Produktdetails anti-EPH Receptor A2 Antikörper

Bindungsspezifität: AA 25-534

Verwendungszweck: Rabbit anti-EphA2 Recombinant Monoclonal Antibody [BLR136H]

Immunogen: residues 25-534 (ECD)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20 μL/1 mg lysate

WB: 01:01,00

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 40 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: EphA2

Hintergrund: Background: Ephrin type-A receptor 2 (EphA2) is a member of the Eph family of tyrosine kinase receptors. Eph receptors have been shown to play a critical role in the development of the nervous system, where they regulate patterning during neural development. The ligands for Eph receptors are ephrins. Ephrin receptors and ligands have been found to be frequently overexpressed in a wide variety of cancers. Contrary to the usual finding that the oncogenic properties of tyrosine kinase receptors are promoted by the autophosphorylation of the receptor, it is the dephosphorylation of EphA2 that is associated with its oncogenic activity. The major study of EphA2 has been in relation to its contribution to malignancy and the possibility of targeting it in cancer therapy.

Gen-ID: 1969

NCBI Accession: NP_004422

UniProt: P29317

Pathways: RTK Signalweg