Huntingtin Antikörper (AA 2300-2350)

Produktnummer ABIN7452517

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Huntingtin in IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Huntingtin Antikörper (AA 2300-2350) (ABIN7452517)

Target: Huntingtin (HTT)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Huntingtin Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-Huntingtin Antikörper

Bindungsspezifität: AA 2300-2350

Verwendungszweck: Rabbit anti-Huntingtin Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 2300 and 2350

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: Not recommended

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Huntingtin

Target: Huntingtin (HTT)

Andere Bezeichnung: Huntingtin

Hintergrund: Background: The Huntingtin (HTT) gene is linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene product is widely expressed and is required for normal development [taken from NCBI Entrez Gene (Gene ID: 3064)].

Gen-ID: 3064

NCBI Accession: NP_002102

UniProt: P42858

Pathways: PI3K-Akt Signalweg, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport