Notch1 Antikörper (AA 2400-2450)
Kurzübersicht für Notch1 Antikörper (AA 2400-2450) (ABIN7452378)
Target
Alle Notch1 (NOTCH1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 2400-2450
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Verwendungszweck
- Rabbit anti-Notch1 Antibody, Affinity Purified
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Homologie
- Mouse,Rat
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 2400 and 2450
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Isotyp
- IgG
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Applikationshinweise
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IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-Notch1 antibody A301-895A.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
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Andere Bezeichnung
- Notch1
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Hintergrund
- Background: Notch1 is the human homolog of the D. melanogaster Notch gene first reported as the gene responsible for the presence of notches in the wingblades of a specific strain of flies. The Notch protein is a transmembrane receptor that mediates juxtacrine signals between adjacent cells. Mammalian Notch1 ligands include Delta-like and Jagged. Upon ligand binding, Notch1 undergoes two proteolytic cleavage events that result in the release of the intracellular Notch1 domain and its translocation to the nucleus where it can participate in gene transactivation. Notch 1 signals mediate cellular fate, differentiation, and development.
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Gen-ID
- 4851
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NCBI Accession
- NP_060087
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UniProt
- P46531
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Pathways
- Notch Signalweg, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Target
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