FIP200 Antikörper (AA 250-300)

Produktnummer ABIN7452328

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FIP200 in IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FIP200 Antikörper (AA 250-300) (ABIN7452328)

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FIP200 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-FIP200 Antikörper

Bindungsspezifität: AA 250-300

Verwendungszweck: Rabbit anti-FIP200/RB1CC1 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 250 and 300

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-FIP200/RB1CC1 antibody ABIN7451783.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu FIP200

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Andere Bezeichnung: FIP200/RB1CC1

Hintergrund: Background: FIP200 (FAK-family interacting protein of 200 kDa) appears to play several key roles related to cell growth, proliferation, development, and tumorigenesis. FIP200 was originally identified in a yeast two-hybrid screen for Pyk2 kinase interacting proteins. It was later identified as a protein that interacts with FAK (focal adhesion kinase), a signal transducing protein that mediates signals from the extracellular matrix to the cytoskeleton to influence cell motility, and cell cycle progression. FIP200 is also known as RB1CC1 (RB1-inducible coiled-coil 1) and has been found to function as a regulator of the retinoblastoma 1 (RB1) tumor suppressor. FIP200 associates with the tumor suppressor TSC1 which partners with TSC2 to antagonize the mTOR signaling pathway. FIP200 association with TSC2 promotes mTOR activity by interfering with the antagonistic effects of the TSC1-TSC2 complex.

Gen-ID: 9821

NCBI Accession: NP_055596

UniProt: Q8TDY2

Pathways: Regulation of Cell Size, Autophagie