BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-50) Antikörper

Produktnummer ABIN7452241

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-50) Antikörper (ABIN7452241)

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails

Bindungsspezifität: AA 1-50

Verwendungszweck: Rabbit anti-MERIT40 Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. ABIN7452241 has not performed satisfactorily when used for WB of MERIT40 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of MERIT40.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Antigendetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Andere Bezeichnung: MERIT40

Hintergrund: Background: MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) Q9NWV8].

Gen-ID: 29086

NCBI Accession: NP_054892

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus