UFD1L Antikörper (AA 175-225)

Produktnummer ABIN7452139

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch UFD1L in WB und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für UFD1L Antikörper (AA 175-225) (ABIN7452139)

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UFD1L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-UFD1L Antikörper

Bindungsspezifität: AA 175-225

Verwendungszweck: Rabbit anti-UFD1 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 175 and 225

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu UFD1L

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Andere Bezeichnung: UFD1

Hintergrund: Background: Ubiquitin fusion degradation protein 1 homolog (UFD1) forms a dimer with Npl4 (nuclear protein localization 4) and can associate with the ATPase, p97/VCP, to form a ternary complex involved in the ubiquitin-proteasome pathway. The UFD1-p97-Npl4 complex functions to recognize ubiquitin-tagged proteins and facilitate their presentation to the 26S proteasome for degradation. This ternary complex has also been shown to play an important role in mitotic spindle disassembly. Hemizygosity in the gene which encodes UFD1 (UFD1L) is the cause of some catch 22-associated developmental defects. Additionally, the UFD1L gene has also been implicated in the neurodevelopment al origin of schizophrenia.

Gen-ID: 7353

NCBI Accession: NP_005650

UniProt: Q92890