NEDD4-2 Antikörper (AA 425-475)
Kurzübersicht für NEDD4-2 Antikörper (AA 425-475) (ABIN7451890)
Target
Alle NEDD4-2 (NEDD4L) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 425-475
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Verwendungszweck
- Rabbit anti-NEDD4L Antibody, Affinity Purified
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Homologie
- Orangutan
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 425 and 475
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Isotyp
- IgG
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Applikationshinweise
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 200 μg/mL
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Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
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Andere Bezeichnung
- NEDD4L
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Hintergrund
- Background: NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) functions as an E3 ubiquitin-protein ligase. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. It also promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5 [taken from the Universal Protein Resource (UniProt) wwwuniprotorg/uniprot/Q96PU5].
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Gen-ID
- 23327
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NCBI Accession
- NP_001138439
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UniProt
- Q96PU5
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Pathways
- Negative Regulation of Transporter Activity
Target
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