ATR Antikörper (AA 1675-1725)
Kurzübersicht für ATR Antikörper (AA 1675-1725) (ABIN7451652)
Target
Alle ATR Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1675-1725
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Verwendungszweck
- Rabbit anti-ATR Antibody, Affinity Purified
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Homologie
- Mouse
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 1675 and 1725
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Isotyp
- IgG
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Applikationshinweise
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- ATR (ATR serine/threonine kinase (ATR))
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Andere Bezeichnung
- ATR
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Hintergrund
- Background: ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.
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Gen-ID
- 545
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NCBI Accession
- NP_001175
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UniProt
- Q13535
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Pathways
- Positive Regulation of Response to DNA Damage Stimulus
Target
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