Polybromo 1 Antikörper (AA 1-50)

Produktnummer ABIN7451294

Der Kaninchen Polyklonal Anti-Polybromo 1-Antikörper wurde für IP validiert. Er ist geeignet, Polybromo 1 in Proben von Human zu detektieren.

Kurzübersicht für Polybromo 1 Antikörper (AA 1-50) (ABIN7451294)

Target: Polybromo 1 (PBRM1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Polybromo 1 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-Polybromo 1 Antikörper

Bindungsspezifität: AA 1-50

Verwendungszweck: Rabbit anti-PBRM1 Antibody, Affinity Purified

Homologie: Mouse

Aufreinigung: Affinity Purified

Immunogen: between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-PBRM1 antibody ABIN7453903.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Polybromo 1

Target: Polybromo 1 (PBRM1)

Andere Bezeichnung: PBRM1

Hintergrund: Background: The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PBRM1 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PBRM1 has been proposed to function as a tumor suppressor protein. Recently, PBRM1 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21.

Gen-ID: 55193

UniProt: Q86U86