PKC eta Antikörper (AA 633-683)

Produktnummer ABIN7450569

Dieses Anti-PKC eta-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PKC eta in WB und IP. Geeignet für Human.

Kurzübersicht für PKC eta Antikörper (AA 633-683) (ABIN7450569)

Target: PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKC eta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-PKC eta Antikörper

Bindungsspezifität: AA 633-683

Verwendungszweck: Rabbit anti-PKC-eta Antibody, Affinity Purified

Homologie: Rat

Aufreinigung: Affinity Purified

Immunogen: Between AA 633 and 683

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PKC eta

Target: PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))

Andere Bezeichnung: PKC-eta

Hintergrund: Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC-eta is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. PKC-eta can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene [taken from NCBI Entrez Gene (Gene ID: 5583)].

Gen-ID: 5583

NCBI Accession: NP_006246

UniProt: P24723

Pathways: Myometrial Relaxation and Contraction, Thromboxane A2 Receptor Signaling