EPH Receptor A2 Antikörper (AA 926-976)

Produktnummer ABIN7450212

Dieses Anti-EPH Receptor A2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EPH Receptor A2 in WB und IP. Geeignet für Human und Maus.

Kurzübersicht für EPH Receptor A2 Antikörper (AA 926-976) (ABIN7450212)

Target: EPH Receptor A2 (EPHA2)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-EPH Receptor A2 Antikörper

Bindungsspezifität: AA 926-976

Verwendungszweck: Rabbit anti-EphA2 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 926 and 976

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: EphA2

Hintergrund: Background: Ephrin type-A receptor 2 (EphA2) is a member of the Eph family of tyrosine kinase receptors. Eph receptors have been shown to play a critical role in the development of the nervous system, where they regulate patterning during neural development. The ligands for Eph receptors are ephrins. Ephrin receptors and ligands have been found to be frequently overexpressed in a wide variety of cancers. Contrary to the usual finding that the oncogenic properties of tyrosine kinase receptors are promoted by the autophosphorylation of the receptor, it is the dephosphorylation of EphA2 that is associated with its oncogenic activity. The major study of EphA2 has been in relation to its contribution to malignancy and the possibility of targeting it in cancer therapy.

Gen-ID: 1969

NCBI Accession: NP_004422

UniProt: P29317

Pathways: RTK Signalweg