Stim2 Antikörper (AA 650-700)
Kurzübersicht für Stim2 Antikörper (AA 650-700) (ABIN7449833)
Target
Alle Stim2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 650-700
-
Verwendungszweck
- Rabbit anti-STIM2 Antibody, Affinity Purified
-
Aufreinigung
- Affinity Purified
-
Immunogen
- Between AA 650 and 700
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
-
IP: 2 - 10 μg/mg lysate
WB: 1:1,000 - 1:5,000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Konzentration
- 1000 μg/mL
-
Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C
-
Haltbarkeit
- 12 months
-
-
- Stim2 (Stromal Interaction Molecule 2 (Stim2))
-
Andere Bezeichnung
- STIM2
-
Hintergrund
- Background: STIM2 (stromal interaction molecule 2) plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Stim2 functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. It regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, STIM2 translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI. STIM2 may inhibit STIM1-mediated Ca(2+) influx [taken from the Universal Protein Resource (UniProt) Q9P246].
-
Gen-ID
- 57620
-
NCBI Accession
- NP_065911
-
UniProt
- Q9P246
-
Pathways
- T-Zell Rezeptor Signalweg, BCR Signaling
Target
-