DIS3L2 Antikörper (AA 475-525)

Produktnummer ABIN7449190

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DIS3L2 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DIS3L2 Antikörper (AA 475-525) (ABIN7449190)

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIS3L2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DIS3L2 Antikörper

Bindungsspezifität: AA 475-525

Verwendungszweck: Rabbit anti-DIS3L2 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 475 and 525

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:10,000 - 1:25,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu DIS3L2

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Andere Bezeichnung: DIS3L2

Hintergrund: Background: DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) Q8IYB7].

Gen-ID: 129563

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance