p107 Antikörper (AA 1018-1068)

Produktnummer ABIN7449079

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch p107 in IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für p107 Antikörper (AA 1018-1068) (ABIN7449079)

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p107 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-p107 Antikörper

Bindungsspezifität: AA 1018-1068

Verwendungszweck: Rabbit anti-RBL1 Antibody, Affinity Purified

Homologie: Mouse

Aufreinigung: Affinity Purified

Immunogen: Between AA 1018 and 1068

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 6 - 15 μL/mg lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu p107

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Andere Bezeichnung: RBL1

Hintergrund: Background: Retinoblastoma-like protein 1 (RBL1) is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. RBL1 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. RBL1 probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It is a potent inhibitor of E2F-mediated trans-activation. RBL1 forms a complex with adenovirus E1A and with SV40 large T antigen and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RBL1 may act as a tumor suppressor [taken from the Universal Protein Resource (UniProt) P28749].

Gen-ID: 5933

UniProt: P28749

Pathways: Zellzyklus, Mitotic G1-G1/S Phases