NUMA1 Antikörper (AA 900-950)

Produktnummer ABIN7448994

Der Kaninchen Polyklonal anti-NUMA1 Antikörper (ABIN7448994) detektiert spezifisch NUMA1 in IHC und IF (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für NUMA1 Antikörper (AA 900-950) (ABIN7448994)

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUMA1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-NUMA1 Antikörper

Bindungsspezifität: AA 900-950

Verwendungszweck: Rabbit anti-NUMA IHC Antibody, Affinity Purified

Homologie: Gorilla,Chimpanzee,Northern white-cheeked gibbon

Aufreinigung: Affinity Purified

Immunogen: Between AA 900 and 950

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Andere Bezeichnung: NUMA

Hintergrund: Background: The nuclear mitotic apparatus protein (NuMA) is a critical component of the mitotic spindle that is responsible for organizing minus-ends of microtubules at spindle poles. NUMA is regulated by phosphorylation and associates with dynein and dynactin in its phosphorylated form. Dephosphorylation of NUMA in anaphase results in the release from dynein and dynactin to allow spindle disassembly. NUMA, in association with dynein and dynactin, also interacts with 4.1R in a complex of spindle pole organizing proteins. Other NUMA interacting proteins include GAS41, tankyrase, and Rae1. These interactions indicate a broader role for NUMA function in the nucleus.

Gen-ID: 4926

NCBI Accession: NP_006176

UniProt: Q14980

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, M Phase