KPNA4 Antikörper (AA 471-521)

Produktnummer ABIN7448983

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KPNA4 in IHC und IF (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für KPNA4 Antikörper (AA 471-521) (ABIN7448983)

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-KPNA4 Antikörper

Bindungsspezifität: AA 471-521

Verwendungszweck: Rabbit anti-KPNA4 IHC Antibody, Affinity Purified

Homologie: Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Chinese hamster,Small-eared galago,Little brown bat,Tasmanian devil,Naked mole rat,African elephant,Thirteen-lined ground squirrel,Northern white-cheeked gibbon,Gray short-tailed opossum

Aufreinigung: Affinity Purified

Immunogen: Between AA 471 and 521

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu KPNA4

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Andere Bezeichnung: KPNA4

Hintergrund: Background: KPNA4 (karyopherin alpha 4), also known as importin alpha 3, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. RNA interference experiments have shown that KPNA4 is important for HeLa cell proliferation and the nuclear import of the Ran guanine nucleotide exchange factor, RCC1.

Gen-ID: 3840

NCBI Accession: NP_002259

UniProt: O00629

Pathways: Protein targeting to Nucleus