MAPKAP1 Antikörper (C-Term)

Produktnummer ABIN7448795

Der Kaninchen Polyklonal Anti-MAPKAP1-Antikörper wurde für IHC validiert. Er ist geeignet, MAPKAP1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für MAPKAP1 Antikörper (C-Term) (ABIN7448795)

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPKAP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-MAPKAP1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit anti-Sin1 IHC Antibody, Affinity Purified

Homologie: Rat,Chicken,Turkey,Sheep,Bovine,Dog,Horse,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Tasmanian devil,Crab-eating macaque,Zebra finch,Small-eared galago,Chinese hamster,Naked mole rat,Gray short-tailed opossum,Thirteen-lined ground squirrel,West Indian ocean coelacanth,Little brown bat,Duckbill platypus

Aufreinigung: Affinity Purified

Immunogen: Between AA 470 and C-term

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu MAPKAP1

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Andere Bezeichnung: Sin1

Hintergrund: Background: Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.

Gen-ID: 79109

NCBI Accession: NP_001006618

UniProt: Q9BPZ7

Pathways: PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events