PRCC Antikörper (AA 125-175)

Produktnummer ABIN7448740

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PRCC in IHC. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für PRCC Antikörper (AA 125-175) (ABIN7448740)

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRCC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-PRCC Antikörper

Bindungsspezifität: AA 125-175

Verwendungszweck: Rabbit anti-PRCC IHC Antibody, Affinity Purified

Homologie: Orangutan,Monkey,Gorilla,Chimpanzee,Northern white-cheeked gibbon

Aufreinigung: Affinity Purified

Immunogen: Between AA 125 and 175

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PRCC

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Andere Bezeichnung: PRCC

Hintergrund: Background: In a subset of papillary renal cell carcinomas, a t(X,1)(p11,q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].

Gen-ID: 5546

NCBI Accession: NP_005964

UniProt: Q92733