BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 175-225) Antikörper

Produktnummer ABIN7448667

Dieses Anti--Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von in IHC. Geeignet für Human.

Kurzübersicht für BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 175-225) Antikörper (ABIN7448667)

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails

Bindungsspezifität: AA 175-225

Verwendungszweck: Rabbit anti-MERIT40 IHC Antibody, Affinity Purified

Homologie: Mouse,Rat,Bovine,Dog,Horse,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,African elephant,Small-eared galago,Chinese hamster,Northern white-cheeked gibbon,Crab-eating macaque,Thirteen-lined ground squirrel,Little brown bat

Aufreinigung: Affinity Purified

Immunogen: Between AA 175 and 225

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Antigendetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Andere Bezeichnung: MERIT40

Hintergrund: Background: MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) Q9NWV8].

Gen-ID: 29086

NCBI Accession: NP_054892

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus