SMAD2 Antikörper

Produktnummer ABIN7384371

Der Kaninchen Monoklonal Anti-SMAD2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, SMAD2 in Proben von Human, Ratte und Hamster zu detektieren.

Kurzübersicht für SMAD2 Antikörper (ABIN7384371)

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Reaktivität: Human, Ratte, Hamster

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SMAD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: R03-3F8

Produktdetails anti-SMAD2 Antikörper

Aufreinigung: Affinity Purified

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:5000 IHC 1:20-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SMAD2

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Andere Bezeichnung: Smad2

Hintergrund: Drosophila,homolog of,MADR2,hMAD-2,HsMAD2,JV18,JV18-1,JV181,MAD,MAD homolog 2,MAD Related Protein 2,Mad-related protein 2,MADH2,MADR2,MGC22139,MGC34440,Mother against DPP homolog 2,Mothers against decapentaplegic homolog 2,Mothers against decapentaplegic,Drosophila,homolog of,2,Mothers against DPP homolog 2,OTTHUMP00000163489,Sma and Mad related protein 2,Sma- and Mad-related protein 2 MAD,SMAD 2,SMAD family member 2,SMAD,mothers against DPP homolog 2,SMAD2,SMAD2,The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Molekulargewicht:

Observed_MW: 52kDa

Calculated_MW: 52kDa

Gen-ID: 4087

UniProt: Q15796

Pathways: Zellzyklus, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus