ALIX Antikörper

Produktnummer ABIN7384341

Der Kaninchen-Monoklonal Anti-ALIX-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von ALIX in Proben aus Human, Ratte und Hamster. }

Kurzübersicht für ALIX Antikörper (ABIN7384341)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reaktivität: Human, Ratte, Hamster

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ALIX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: R03-8C2

Produktdetails anti-ALIX Antikörper

Aufreinigung: Affinity Purified

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Andere Bezeichnung: ALIX

Hintergrund: PDCD6IP,AIP1,ALIX,DRIP4,HP95,This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Molekulargewicht:

Observed_MW: 96kDa

Calculated_MW: 96kDa

Gen-ID: 10015

UniProt: Q8WUM4

Pathways: p53 Signalweg, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation