UBE2O Antikörper (AA 1073-1292)

Produktnummer ABIN7271180

Der Kaninchen Polyklonal Anti-UBE2O-Antikörper wurde für IHC validiert. Er ist geeignet, UBE2O in Proben von Human zu detektieren.

Kurzübersicht für UBE2O Antikörper (AA 1073-1292) (ABIN7271180)

Target: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2O Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-UBE2O Antikörper

Bindungsspezifität: AA 1073-1292

Verwendungszweck: UBE2O Rabbit pAb

Sequenz: LVNEPYYNEA GFDSDRGLQE GYENSRCYNE MALIRVVQSM TQLVRRPPEV FEQEIRQHFS TGGWRLVNRI ESWLETHALL EKAQALPNGV PKASSSPEPP AVAELSDSGQ QEPEDGGPAP GEASQGSDSE GGAQGLASAS RDHTDQTSET APDASVPPSV KPKKRRKSYR SFLPEKSGYP DIGFPLFPLS KGFIKSIRGV LTQFRAALLE AGMPECTEDK

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1073-1292 of human UBE2O (NP_071349.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu UBE2O

Target: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Andere Bezeichnung: UBE2O

Hintergrund: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.,UBE2O,E2-230K,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,UBE2O

Molekulargewicht: 141kDa

Gen-ID: 63893

UniProt: Q9C0C9