USP37 Antikörper (AA 150-250)
Kurzübersicht für USP37 Antikörper (AA 150-250) (ABIN7271158)
Target
Alle USP37 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 150-250
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Verwendungszweck
- USP37 Rabbit pAb
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Sequenz
- SLETKDDIPF RKVLGNPGRG SIKTVAGSGI ARTIPSLTST STPLRSGLLE NRTEKRKRMI STGSELNEDY PKENDSSSNN KAMTDPSRKY LTSSREKQLS L
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Kreuzreaktivität
- Human, Maus, Ratte
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Produktmerkmale
- Polyclonal Antibodies
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Aufreinigung
- Affinity purification
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Immunogen
- A synthetic peptide corresponding to a sequence within amino acids 150-250 of human USP37 (NP_065986.2).
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Isotyp
- IgG
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Applikationshinweise
- WB,1:500 - 1:2000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- USP37 (Ubiquitin Specific Peptidase 37 (USP37))
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Andere Bezeichnung
- USP37
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Hintergrund
- Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2. Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.,USP37,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,USP37
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Molekulargewicht
- 99kDa/110kDa
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Gen-ID
- 57695
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UniProt
- Q86T82
Target
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