SRRT Antikörper (AA 623-872)

Produktnummer ABIN7270253

Der Kaninchen Polyklonal Anti-SRRT-Antikörper wurde für IHC validiert. Er ist geeignet, SRRT in Proben von Human zu detektieren.

Kurzübersicht für SRRT Antikörper (AA 623-872) (ABIN7270253)

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRRT Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-SRRT Antikörper

Bindungsspezifität: AA 623-872

Verwendungszweck: SRRT Rabbit pAb

Sequenz: DYYNTCEYPN EDEMPNRCGI IHVRGPMPPN RISHGEVLEW QKTFEEKLTP LLSVRESLSE EEAQKMGRKD PEQEVEKFVT SNTQELGKDK WLCPLSGKKF KGPEFVRKHI FNKHAEKIEE VKKEVAFFNN FLTDAKRPAL PEIKPAQPPG PAQSLTPGLP YPHQTPQGLM PYGQPRPPIL GYGAGAVRPA VPTGGPPYPH APYGAGRGNY DAFRGQGGYP GKPRNRMVRG DPRAIVEYRD LDAPDDVDFF

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SRRT

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Andere Bezeichnung: SRRT

Hintergrund: Acts as a mediator between the cap-binding complex (CBC and the primary microRNAs (miRNAs processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi by miRNAs. Binds capped RNAs (m7GpppG-capped RNA, however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity.,SRRT,ARS2,ASR2,serrate,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Drug metabolism,SRRT

Molekulargewicht: 96kDa/100kDa

Gen-ID: 51593

UniProt: Q9BXP5

Pathways: Notch Signalweg, Stem Cell Maintenance