AMFR Antikörper (AA 85-180)

Produktnummer ABIN717371

Produktdetails anti-AMFR Antikörper

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Bindungsspezifität: AA 85-180

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AMFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AMFR/RNF45

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu AMFR

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Andere Bezeichnung: RNF45 (AMFR Produkte)

Synonyme: GP78 antikoerper, RNF45 antikoerper, gp78 antikoerper, wu:fi06e06 antikoerper, wu:fi37e05 antikoerper, zgc:63893 antikoerper, rnf45 antikoerper, autocrine motility factor receptor antikoerper, autocrine motility factor receptor L homeolog antikoerper, autocrine motility factor receptor a antikoerper, autocrine motility factor receptor, amfr antikoerper, putative autocrine motility factor receptor, amfr antikoerper, AMFR antikoerper, Amfr antikoerper, amfr.L antikoerper, amfra antikoerper, amfr antikoerper, AaeL_AAEL005881 antikoerper, CpipJ_CPIJ016043 antikoerper, Smp_047420 antikoerper

Hintergrund:

Synonyms: AMF receptor, AMF receptor isoform 1, AMF receptor isoform 2, AMFR, AMFR2_HUMAN, Autocrine motility factor receptor, Autocrine motility factor receptor precursor, isoform 1, Autocrine motility factor receptor precursor, isoform 2, E3 ubiquitin-protein ligase AMFR, gp78, RING finger protein 45, RNF 45, RNF45.

Background: E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR, proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.

Gen-ID: 267

Pathways: ER-Nucleus Signaling