MAP3K3 Antikörper

Produktnummer ABIN7268651

Der Kaninchen Monoklonal anti-MAP3K3 Antikörper wird verwendet zum Nachweis von MAP3K3 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für MAP3K3 Antikörper (ABIN7268651)

Target: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MAP3K3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAP3K3 Antikörper

Verwendungszweck: MEKK3 Rabbit mAb

Kreuzreaktivität: Human, Maus

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human MEKK3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MAP3K3

Target: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Andere Bezeichnung: MAP3K3

Hintergrund: This gene product is a 626-amino acid polypeptide that is 96.5 % identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively, it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],MAPKKK3, MEKK3,B Cell Receptor Signaling Pathway,Cell Biology & Developmental Biology,Cell Intrinsic Innate Immunity Signaling Pathway,Cytoskeleton,Cytoskeleton_Actins,Immunology & Inflammation,Innate Immunity_TLR Signaling,Kinase,Kinase_Serine/threonine kinases,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Signal Transduction,Toll-like Receptor Signaling Pathway,MAP3K3

Molekulargewicht: 71kDa

Gen-ID: 4215

UniProt: Q99759

Pathways: MAPK Signalweg