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IGHM Antikörper

This anti-IGHM antibody (ABIN7267845) is a Rabbit Monoclonal antibody detecting IGHM in IHC, WB. Suitable for Human.
Produktnummer ABIN7267845

Kurzübersicht für IGHM Antikörper (ABIN7267845)

Target

IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Reaktivität

  • 27
  • 1
  • 1
Human

Wirt

  • 14
  • 13
Kaninchen

Klonalität

  • 17
  • 10
Monoklonal

Konjugat

  • 23
  • 1
  • 1
  • 1
  • 1
Dieser IGHM Antikörper ist unkonjugiert

Applikation

  • 14
  • 13
  • 12
  • 8
  • 7
  • 7
  • 6
  • 4
  • 2
  • 1
  • 1
Immunohistochemistry (IHC), Western Blotting (WB)
  • Verwendungszweck

    Human IgM Rabbit mAb

    Kreuzreaktivität

    Human

    Produktmerkmale

    Monoclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    A synthesized peptide derived from human Human IgM

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IHC,1:50 - 1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    IGHM (Immunoglobulin Heavy Constant mu (IGHM))

    Andere Bezeichnung

    IGHM

    Hintergrund

    Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes, joining (J) genes, and diversity (D) genes. The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma.,AGM1, MU, VH,Immunology & Inflammation,IGHM

    Molekulargewicht

    75kDa

    Gen-ID

    3507

    UniProt

    P01871
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