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DDB1 Antikörper

This anti-DDB1 antibody (ABIN7266673) is a Rabbit Monoclonal antibody detecting DDB1 in WB, IHC, IP. Suitable for Human.
Produktnummer ABIN7266673

Quick Overview for DDB1 Antikörper (ABIN7266673)

Target

Alle DDB1 Antikörper anzeigen
DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Reaktivität

  • 46
  • 25
  • 21
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 37
  • 8
  • 1
Kaninchen

Klonalität

  • 36
  • 10
Monoklonal

Konjugat

  • 35
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DDB1 Antikörper ist unkonjugiert

Applikation

  • 31
  • 15
  • 15
  • 15
  • 10
  • 10
  • 9
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • Verwendungszweck

    DDB1 Rabbit mAb

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Monoclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    A synthesized peptide derived from human DDB1

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

    Andere Bezeichnung

    DDB1

    Hintergrund

    The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012],DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF,Cancer,Carbohydrate metabolism,Cell Biology & Developmental Biology,DNA Damage & Repair,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,Neurodegenerative Diseases,Neurodegenerative Diseases_Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease,Neuroscience,Signal Transduction,Ubiquitin,Ubiquitin_Ubiquitin-Proteasome Signaling Pathway,DDB1

    Molekulargewicht

    127kDa

    Gen-ID

    1642

    UniProt

    Q16531

    Pathways

    DNA Reparatur
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