C4A Antikörper (AA 1200-1446)

Produktnummer ABIN7266482

Der Kaninchen Polyklonal Anti-C4A-Antikörper wurde für WB validiert. Er ist geeignet, C4A in Proben von Human zu detektieren.

Kurzübersicht für C4A Antikörper (AA 1200-1446) (ABIN7266482)

Target: C4A (C4a) (Complement Fragment C4a (C4a))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-C4A Antikörper

Bindungsspezifität: AA 1200-1446

Verwendungszweck: Complement C4A Rabbit pAb

Sequenz: LTLTKAPVDL LGVAHNNLMA MAQETGDNLY WGSVTGSQSN AVSPTPAPRN PSDPMPQAPA LWIETTAYAL LHLLLHEGKA EMADQASAWL TRQGSFQGGF RSTQDTVIAL DALSAYWIAS HTTEERGLNV TLSSTGRNGF KSHALQLNNR QIRGLEEELQ FSLGSKINVK VGGNSKGTLK VLRTYNVLDM KNTTCQDLQI EVTVKGHVEY TMEANEDYED YEYDELPAKD DPDAPLQPVT PLQLFEG

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1200-1446 of human Complement C4A (NP_009224.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu C4A

Target: C4A (C4a) (Complement Fragment C4a (C4a))

Andere Bezeichnung: C4A

Hintergrund: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.,C4A,C4,C4A2,C4A3,C4A4,C4A6,C4AD,C4S,CO4,CPAMD2,RG,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,C4A

Molekulargewicht: 187kDa/192kDa

Gen-ID: 720

UniProt: P0C0L4

Pathways: Komplementsystem