Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

TMC1 Antikörper (Extracellular)

TMC1 Reaktivität: Maus WB, IF (cc), LCI Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7237916
  • Target Alle TMC1 Antikörper anzeigen
    TMC1 (Transmembrane Channel-Like 1 (TMC1))
    Bindungsspezifität
    Extracellular
    Reaktivität
    • 4
    • 2
    • 2
    Maus
    Wirt
    • 4
    Kaninchen
    Klonalität
    • 4
    Polyklonal
    Konjugat
    • 4
    Dieser TMC1 Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
    Verwendungszweck
    A Rabbit Polyclonal antibody to TMC1 (extracellular) 
    Spezifität
    Extracellular, 3rd loop. 
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Rat,human - identical
    Produktmerkmale
    Extracellular, 3rd loop
    Aufreinigung
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)EHDFPSWMAKILR, corresponding to amino acid residues 679 - 691 of mouse TMC1

    Isotyp
    IgG
    Top Product
    Discover our top product TMC1 Primärantikörper
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:200-1:400

    Kommentare

    Negative Control: BLP-TC010

    Blocking Peptide: BLP-TC010

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    TMC1 (Transmembrane Channel-Like 1 (TMC1))
    Andere Bezeichnung
    TMC1  (TMC1 Produkte)
    Hintergrund
    Transmembrane Channel Like 1, Transmembrane cochlear-expressed protein 1,Transmembrane channel-like protein 1 (TMC1) is one of eight mammalian TMC genes. Proteins that belong to this family contain six transmembrane domains with both the C and N termini on the cytoplasmic side of the membrane, as well as a large loop between domains 4 and 5. This multi-pass transmembrane topologic structure suggests roles as a receptor, transporter, channel, or pump1. TMC1 and the closely related TMC2 gene are assembled as dimers2 and are expressed in neurosensory hair cells of the mouse inner ear where they appear to have a role as pore forming units in mechanoelectrical transduction. Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice3 and hence, identification of the molecular functions of Tmc genes is broadly significant because it may provide a handle on the fundamental mechanisms that mediate human hearing and balance4.

    Alternative names: Transmembrane Channel Like 1, Transmembrane cochlear-expressed protein 1
    Gen-ID
    13409
    NCBI Accession
    NM_138691
    UniProt
    Q8R4P5
    Pathways
    Sensory Perception of Sound
Sie sind hier:
Kundenservice