GABARAPL1 Antikörper (C-Term)

Produktnummer ABIN7233060

Dieses Anti-GABARAPL1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GABARAPL1 in WB und IF/ICC. Geeignet für Human.

Kurzübersicht für GABARAPL1 Antikörper (C-Term) (ABIN7233060)

Target: GABARAPL1 (GABA(A) Receptor-Associated Protein Like 1 (GABARAPL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABARAPL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)

Produktdetails anti-GABARAPL1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-GABARAPL1 Rabbit Polyclonal Antibody

Spezifität: This antibody recognizes human GABARAPL1.

Kreuzreaktivität: Human

Immunogen: Synthetic peptide corresponding to the C-terminus of human GABARAPL1

Anwendungsinformationen

Applikationshinweise: Immunoblotting: use at dilution of 1:1,000. A band of ~14-16 kDa is detected.
Immunofluorescence: use at dilution of 1:100
These are recommended working dilutions.
Endusers should determine optimal dilutions for their applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: This antibody is stable for at least one (1) year at -20°C.

Details zu GABARAPL1

Target: GABARAPL1 (GABA(A) Receptor-Associated Protein Like 1 (GABARAPL1))

Andere Bezeichnung: GABARAPL1

Hintergrund: γ-aminobutyric acid receptor-associated protein-like 1,Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). {PubMed:16431922, PubMed:20404487, PubMed:31006537, PubMed:31006538}.,GABARAP, GABARAPL1 and GABARAPL2 genes are differentially expressed in normal and pathological tissues. The GABARAP gene is highly expressed in endocrine tissues while the GABARAPL1 gene is predominantly expressed in the central nervous system, but they both are underexpressed in a large variety of cancer cell lines. However, the analysis of GABARAPL1 expression in a cohort of 256 breast adenocarcinoma revealed that a low GABARAPL1 expression was correlated with a high risk of metastasis, in particular for lymph node-positive patients.,Cytoplasmic vesicle, autophagosome, Cytoplasmic vesicle membrane, Cytoplasm, cytoskeleton, Endoplasmic reticulum, Golgi apparatus,Early estrogen-regulated protein, GABA(A receptor-associated protein-like 1, Glandular epithelial cell protein 1, GEC-1

UniProt: Q9H0R8

Pathways: Autophagie