FPR1 Antikörper

Produktnummer ABIN7232897

Der Maus Monoklonal Anti-FPR1-Antikörper wurde für WB und IF validiert. Er ist geeignet, FPR1 in Proben von Human zu detektieren.

Kurzübersicht für FPR1 Antikörper (ABIN7232897)

Target: FPR1 (Formyl Peptide Receptor 1 (FPR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FPR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: NFPR1

Produktdetails anti-FPR1 Antikörper

Verwendungszweck: Anti-FPR1/2 MAb Mouse Monoclonal Antibody

Spezifität: This antibody recognizes human FPR1 at aa 305-GQDFRERLI-313 at the amino- terminal portion of the carboxyl-terminal tail. It also recognizes the same epitope in FPR2.

Kreuzreaktivität: Human

Immunogen: His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunoblotting: use at 1-5 μg/mL.
Immunofluorescence: use at 10 μg/mL.
These are recommended concentrations.
Enduser should determine optimal concentrations for their application.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Konzentration: Lot specific

Buffer: PBS, pH 7.4

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: This product is stable for at least one (1)year at -20°C to -70 C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Details zu FPR1

Target: FPR1 (Formyl Peptide Receptor 1 (FPR1))

Andere Bezeichnung: FPR1

Hintergrund: FMet-Leu-Phe receptor,High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium sPubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894, PubMed:25109685, PubMed:10514456, PubMed:1712023, PubMed:2161213, PubMed:2176894}.,Formyl peptide receptors (FPR) are G protein-coupled receptors that are activated by different agonists included N- formylated peptides originating from bacteria and mitochondria. In humans, the FPR family includes the high affinity FPR1, the low affinity FPR2/ALX (previously known as FPRL1 or ALX) and FPR3. Human FPR1 is important for phagocyte chemotaxis, superoxide production, and degranulation, and helps direct phagocytes to sites of infection. Functional FPR1expression has been demonstrated on fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and on several types of epithelial cells.,Cell membrane,fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor

UniProt: P21462