TGIF1 Antikörper (C-Term)

Produktnummer ABIN7224686

Dieser Anti-TGIF1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von TGIF1 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TGIF1 Antikörper (C-Term) (ABIN7224686)

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGIF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TGIF1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: TGIF Polyclonal Antibody

Spezifität: TGIF Polyclonal Antibody detects endogenous levels of TGIF protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human TGIF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu TGIF1

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Andere Bezeichnung: TGIF

Hintergrund: Rabbit Anti-TGIF Polyclonal Antibody,TGIF1, TGIF, Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1,The protein encoded by TGIF1 (TGFB induced factor homeobox 1) is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in TGIF1 are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.,Homeobox protein TGIF1

Molekulargewicht: observerd band 43kDa

Gen-ID: 7050

UniProt: Q15583

Pathways: Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation