TAL1 Antikörper

Produktnummer ABIN7224606

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TAL1 in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für TAL1 Antikörper (ABIN7224606)

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-TAL1 Antikörper

Verwendungszweck: Rabbit Anti-TAL1 Polyclonal Antibody

Spezifität: TAL1 Polyclonal Antibody detects endogenous levels of TAL1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human TAL1 around the non-phosphorylation site of S122

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Andere Bezeichnung: TAL1

Hintergrund: TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings. The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding. TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells , and is required for maturation of erythroid and megakaryocytic lineages in the adult. TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1. Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL). TAL1 activity is essential for both hematopoiesis and neurogenesis.

Molekulargewicht: 45kD

Gen-ID: 6886

UniProt: P17542

Pathways: Stem Cell Maintenance