POLE Antikörper (AA 1230-1310)

Produktnummer ABIN7223256

Der Kaninchen Polyklonal anti-POLE Antikörper (ABIN7223256) detektiert spezifisch POLE in ELISA, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für POLE Antikörper (AA 1230-1310) (ABIN7223256)

Target: POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLE Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-POLE Antikörper

Bindungsspezifität: AA 1230-1310

Verwendungszweck: Rabbit Anti-DNA pol ε A Polyclonal Antibody

Spezifität: DNA pol ε A Polyclonal Antibody detects endogenous levels of DNA pol ε A protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human DNA pol epsilon A at AA range: 1230-1310

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu POLE

Target: POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit (POLE))

Andere Bezeichnung: DNA pol epsilon A

Hintergrund: POLE, POLE1, DNA polymerase epsilon catalytic subunit A, DNA polymerase II subunit APOLE (DNA polymerase epsilon, catalytic subunit) encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in POLE have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature.

Gen-ID: 5426

UniProt: Q07864

Pathways: Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA