PAX5 Antikörper (AA 1-80)

Produktnummer ABIN7216458

Der Kaninchen Polyklonal anti-PAX5 Antikörper (ABIN7216458) detektiert spezifisch PAX5 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für PAX5 Antikörper (AA 1-80) (ABIN7216458)

Target: PAX5 (Paired Box 5 (PAX5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PAX5 Antikörper

Bindungsspezifität: AA 1-80

Verwendungszweck: Rabbit Anti-Pax-5 Polyclonal Antibody

Spezifität: Pax-5 Polyclonal Antibody detects endogenous levels of Pax-5 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human Pax-5 at AA range: 1-80

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu PAX5

Target: PAX5 (Paired Box 5 (PAX5))

Andere Bezeichnung: Pax-5

Hintergrund: PAX5, Paired box protein Pax-5, B-cell-specific transcription factor, BSAPPAX5 encodes a member of the paired box (PAX) family of transcription factors. The central feature of PAX5 family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of PAX5 are thought to contribute to neoplastic transformation. PAX5 encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the paired box 5 may also play a role in neural development and spermatogenesis. PAX5 is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of PAX5 contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 40kD

Gen-ID: 5079

UniProt: Q02548