NOTCH4 Antikörper (Cleaved-Val1432)

Produktnummer ABIN7222800

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch NOTCH4 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human und Affe.

Kurzübersicht für NOTCH4 Antikörper (Cleaved-Val1432) (ABIN7222800)

Target: NOTCH4 (Notch 4 (NOTCH4))

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTCH4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-NOTCH4 Antikörper

Bindungsspezifität: AA 1370-1450, Cleaved-Val1432

Verwendungszweck: Cleaved-Notch 4 (V1432) Polyclonal Antibody

Spezifität: Cleaved-Notch 4 (V1432) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 4 protein resulting from cleavage adjacent to V1432.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Notch 4 at AA range: 1370-1450

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu NOTCH4

Target: NOTCH4 (Notch 4 (NOTCH4))

Andere Bezeichnung: Notch 4

Hintergrund: Rabbit Anti-Cleaved-Notch 4 (V1432) Polyclonal Antibody,NOTCH4, INT3, Neurogenic locus notch homolog protein 4, Notch 4, hNotch4,NOTCH4 encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in NOTCH4 may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.,Neurogenic locus notch homolog protein 4

Molekulargewicht: observerd band 59kDa

Gen-ID: 4855

UniProt: Q99466

Pathways: Notch Signalweg