NOTCH4 Antikörper (Notch 4) (Middle Region)

Details for Product anti-NOTCH4 Antibody No. ABIN2777550, Anbieter: Anmelden zum Anzeigen
Antigen
  • INT3
  • NOTCH3
  • Int-3
  • Int3
  • N4
  • Notch4
  • notch 4
  • neurogenic locus notch homolog protein 4
  • NOTCH4
  • Notch4
  • LOC100712850
Epitop
Middle Region
22
4
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Meerschweinchen, Pferd, Human, Schwein, Ratte (Rattus)
70
29
12
5
5
4
3
3
2
1
Wirt
Kaninchen
58
11
9
6
2
Klonalität
Polyklonal
Konjugat
Dieser NOTCH4 Antikörper ist unkonjugiert
4
2
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
56
40
24
15
8
8
8
5
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human NOTCH4
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN980812.
Sequenz LLLGLGAARE LRDQAGLAPA DVAHQRNHWD LLTLLEGAGP PEARHKATPG
Homologie Cow: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Pig: 100%, Rat: 93%
Produktmerkmale This is a rabbit polyclonal antibody against NOTCH4. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Plasmids, Primers & others Plasmide, Primers & weitere NOTCH4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung NOTCH4 (NOTCH4 Antibody Abstract)
Hintergrund NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases.
Alias Symbols: INT3, NOTCH4
Protein Interaction Partner: EGFL7, Dlg4, SMAD4, SMAD3, SMAD2, TCEB1, UBC, TP53, MDM2, MAML3, MAML2, FBXW7, MAML1, DLL4, PSEN2, NOTCH4, RBPJ, PSEN1,
Protein Size: 589
Molekulargewicht 61 kDa
Gen-ID 4855
Pathways Notch Signalweg
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 589 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Notch 4 (NOTCH4) (Middle Region) antibody (ABIN2777550) WB Suggested Anti-NOTCH4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Po...
Immunohistochemistry (IHC) image for anti-Notch 4 (NOTCH4) (Middle Region) antibody (ABIN2777550) Immunohistochemistry with Human Breast tissue at an antibody concentration of 5.0ug/m...
Immunohistochemistry (IHC) image for anti-Notch 4 (NOTCH4) (Middle Region) antibody (ABIN2777550) Immunohistochemistry with Human Breast tissue at an Antibody concentration of 5.0 µg/...
Western Blotting (WB) image for anti-Notch 4 (NOTCH4) (Middle Region) antibody (ABIN2777550) Host: Rabbit Target Name: NOTCH4 Sample Tissue: Human Lung Tumor Antibody Dilut...
Produkt verwendet in: Bhat, Sun, Weger, Raouf: "Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells." in: Stem cells and development, Vol. 25, Issue 7, pp. 522-9, 2016 (PubMed).

Sun, Klauzinska, Lake, Lee, Santopietro, Raafat, Salomon, Callahan, Artavanis-Tsakonas: "Trp53 regulates Notch 4 signaling through Mdm2." in: Journal of cell science, Vol. 124, Issue Pt 7, pp. 1067-76, 2011 (PubMed).

Sugaya, Sasanuma, Nohata, Kimura, Fukagawa, Nakamura, Ando, Inoko, Ikemura, Mita: "Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3." in: Gene, Vol. 189, Issue 2, pp. 235-44, 1997 (PubMed).

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