NSG2 Antikörper (AA 10-90)

Produktnummer ABIN7223076

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NSG2 in IHC, ELISA, WB und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für NSG2 Antikörper (AA 10-90) (ABIN7223076)

Target: NSG2 (HMP19) (Neuron-Specific Protein Family Member 2 (HMP19))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSG2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-NSG2 Antikörper

Bindungsspezifität: AA 10-90

Verwendungszweck: Rabbit Anti-HMP19 Polyclonal Antibody

Spezifität: HMP19 Polyclonal Antibody detects endogenous levels of HMP19 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human HMP19 at AA range: 10-90

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu NSG2

Target: NSG2 (HMP19) (Neuron-Specific Protein Family Member 2 (HMP19))

Andere Bezeichnung: HMP19

Hintergrund: NSG2, Neuron-specific protein family member 2, Protein p19, Hmp19The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells. Normal precursor cells and malignant tumor cells migrate and proliferate, but there is evidence that cells may not be able to engage in both activities at the same time. However, NG2 is involved in promoting both proliferation and motility. The extracellular domain of NG2 sequesters growth factors and binds to both growth factor receptors and extracellular matrix ligands such as fibronectin, collagens and laminin. The cytoplasmic domain is involved in activating Rac, Cdc42 and p130 Cas. PKCα phosphorylates NG2 at Thr2256, triggering the redistribution of NG2 from apical microprocesses to lamellipodia accompanied by enhanced cell motility. ERK phosphorylates NG2 at Thr2314, stimulating cell proliferation.

Molekulargewicht: 19kD

Gen-ID: 51617

UniProt: Q9Y328