Neuregulin 3 Antikörper (Internal Region)

Produktnummer ABIN7226724

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Neuregulin 3 in WB, ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für Neuregulin 3 Antikörper (Internal Region) (ABIN7226724)

Target: Neuregulin 3 (NRG3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Neuregulin 3 Antikörper

Bindungsspezifität: Internal Region

Verwendungszweck: Neuregulin-3 Polyclonal Antibody

Spezifität: Neuregulin-3 Polyclonal Antibody detects endogenous levels of Neuregulin-3 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Neuregulin-3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Neuregulin 3

Target: Neuregulin 3 (NRG3)

Andere Bezeichnung: Neuregulin-3

Hintergrund: Rabbit Anti-Neuregulin-3 Polyclonal Antibody,NRG3, Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3,NRG3 (neuregulin 3) is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated NRG3 as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.,Pro-neuregulin-3 membrane-bound isoform

Molekulargewicht: observerd band 80kDa

Gen-ID: 10718

UniProt: P56975

Pathways: RTK Signalweg