NBR1 Antikörper

Produktnummer ABIN7212362

Der Maus Monoklonal anti-NBR1 Antikörper wird verwendet zum Nachweis von NBR1 in Proben von Human, Maus und Ratte. Er wurde validiert für IF und IHC.

Kurzübersicht für NBR1 Antikörper (ABIN7212362)

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NBR1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (IHC)

Klon: 7C3

Produktdetails anti-NBR1 Antikörper

Verwendungszweck: Mouse Anti-NBR1 Mouse Monoclonal Antibody (7C3)

Spezifität: The antibody detects endogenous NBR1 protein.

Aufreinigung: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Recombinant Protein of NBR1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu NBR1

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Andere Bezeichnung: NBR1

Hintergrund: Next to BRCA1 gene 1 protein, Cell migration-inducing gene 19 protein, Membrane component chromosome 17 surface marker 2, Neighbor of BRCA1 gene 1 protein, Protein 1A1-3BThe protein encoded by NBR1 (NBR1, autophagy cargo receptor) was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. NBR1 is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of NBR1 results in multiple transcript variants.

Molekulargewicht: 120kD

Gen-ID: 4077

UniProt: Q14596

Pathways: Autophagie