MIA3 Antikörper (AA 1110-1190)

Produktnummer ABIN7229662

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MIA3 in ELISA und WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für MIA3 Antikörper (AA 1110-1190) (ABIN7229662)

Target: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIA3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-MIA3 Antikörper

Bindungsspezifität: AA 1110-1190

Verwendungszweck: Rabbit Anti-MIA3 Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of MIA3 protein

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MIA3 protein at AA range: 1110-1190

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu MIA3

Target: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Andere Bezeichnung: MIA3

Hintergrund: Transport and Golgi organization protein 1 homolog, TANGO1, C219-reactive peptide, D320, Melanoma inhibitory activity protein 3MIA3 (MIA Family Member 3, ER Export Factor) is a Protein Coding gene. Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum.

Molekulargewicht: 209kD

Gen-ID: 375056

UniProt: Q5JRA6