MIA3 Antikörper (AA 1447-1626)

Produktnummer ABIN7173309

Produktdetails anti-MIA3 Antikörper

Target: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Bindungsspezifität: AA 1447-1626

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIA3 Antikörper ist unkonjugiert

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Transport and Golgi organization protein 1 homolog protein (1447-1626AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MIA3

Target: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Andere Bezeichnung: MIA3 (MIA3 Produkte)

Synonyme: CG11098 antikoerper, Dmel\\CG11098 antikoerper, TANGO1 antikoerper, MIA3 antikoerper, 9130229H14Rik antikoerper, A930039G15Rik antikoerper, AU022327 antikoerper, B230399H06Rik antikoerper, C80126 antikoerper, Gm1525 antikoerper, Tango antikoerper, ARNT antikoerper, D320 antikoerper, TANGO antikoerper, UNQ6077 antikoerper, Transport and Golgi organization 1 antikoerper, MIA family member 3, ER export factor antikoerper, melanoma inhibitory activity family, member 3 antikoerper, melanoma inhibitory activity protein 3 antikoerper, melanoma inhibitory activity family member 3 antikoerper, melanoma inhibitory activity 3 antikoerper, Tango1 antikoerper, MIA3 antikoerper, LOC100055507 antikoerper, mia3 antikoerper, Mia3 antikoerper

Hintergrund:

Background: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of CTAGE5 and PREB/SEC12 to ERES (PubMed:28442536).

Aliases: ARNT antibody, C219 reactive peptide antibody, C219-reactive peptide antibody, D320 antibody, Melanoma inhibitory activity family, member 3 antibody, Melanoma inhibitory activity protein 3 antibody, Mia3 antibody, MIA3_HUMAN antibody, RP11-378J18.4 antibody, TANGO antibody, Transport and Golgi organization protein 1 antibody, UNQ6077 antibody

UniProt: Q5JRA6