MADD Antikörper (AA 720-800)

Produktnummer ABIN7215662

Der Kaninchen Polyklonal Anti-MADD Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, MADD in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für MADD Antikörper (AA 720-800) (ABIN7215662)

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MADD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MADD Antikörper

Bindungsspezifität: AA 720-800

Verwendungszweck: MADD Polyclonal Antibody

Spezifität: MADD Polyclonal Antibody detects endogenous levels of MADD protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human MADD at AA range: 720-800

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu MADD

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Andere Bezeichnung: MADD

Hintergrund: Rabbit Anti-MADD Polyclonal Antibody,MADD, DENN, IG20, KIAA0358, MAP kinase-activating death domain protein, Differentially expressed in normal and neoplastic cells, Insulinoma glucagonoma clone 20, Rab3 GDP/GTP exchange factor,Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. MAP kinase-activating death domain protein encoded by MADD is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.,MAP kinase-activating death domain protein

Molekulargewicht: observerd band 183kDa

Gen-ID: 8567

UniProt: Q8WXG6

Pathways: Caspase Kaskade in der Apoptose