Macrophage Scavenger Receptor 1 Antikörper (AA 241-290)

Produktnummer ABIN7227706

Der Kaninchen Polyklonal anti-Macrophage Scavenger Receptor 1 Antikörper wird verwendet zum Nachweis von Macrophage Scavenger Receptor 1 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, IHC und IF.

Kurzübersicht für Macrophage Scavenger Receptor 1 Antikörper (AA 241-290) (ABIN7227706)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Macrophage Scavenger Receptor 1 Antikörper

Bindungsspezifität: AA 241-290

Verwendungszweck: Rabbit Anti-CD204 Polyclonal Antibody

Spezifität: The antibody detects endogenous levels of CD204

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CD204 protein at AA range: 241-290

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Andere Bezeichnung: CD204

Hintergrund: Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD antigen CD204MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of MSR1. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Gen-ID: 4481

UniProt: P21757