Macrophage Scavenger Receptor 1 Antikörper (AA 275-451)

Produktnummer ABIN7193254

Produktdetails anti-Macrophage Scavenger Receptor 1 Antikörper

Target: Macrophage Scavenger Receptor 1 (MSR1)

Bindungsspezifität: AA 275-451

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Neutralization (Neut)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human CD204 (AA: extra 275-451) expressed in E. coli.

Klon: 5B8H4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Andere Bezeichnung: CD204 (MSR1 Produkte)

Synonyme: CD204 antikoerper, SCARA1 antikoerper, SR-A antikoerper, SRA antikoerper, phSR1 antikoerper, phSR2 antikoerper, MRS-A antikoerper, MSR antikoerper, MSR-A antikoerper, SR-AI antikoerper, SR-AII antikoerper, Scara1 antikoerper, Scvr antikoerper, MSR1 antikoerper, RGD1564316 antikoerper, macrophage scavenger receptor 1 antikoerper, scavenger receptor class A member 5 antikoerper, MSR1 antikoerper, Msr1 antikoerper, SCARA5 antikoerper

Hintergrund:

Description: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Aliases: MSR1, SRA, SR-A, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII

Molekulargewicht: 49.8 kDa

Gen-ID: 4481